FMR1 antibody (C-Term)

Catalog No. ABIN6991972

This Rabbit Polyclonal antibody specifically detects FMR1 in WB, ELISA, IF and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FMR1 antibody (C-Term) (ABIN6991972)

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FMR1 Antibody

Binding Specificity: C-Term

Specificity: FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.

Purification: FMR1 antibody is affinity chromatography purified via peptide column.

Immunogen: FMR1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FMR1. The immunogen is located within the last 50 amino acids of FMR1.

Isotype: IgG

Application Details

Application Notes: FMR1 antibody can be used for detection of FMR1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: FMR1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: FMR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for FMR1

Target: FMR1 (Fragile X Mental Retardation 1 (FMR1))

Alternative Name: FMR1

Background: Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).

Molecular Weight: Predicted: 70 kDa

Observed: 74 kDa

Gene ID: 2332

NCBI Accession: NP_002015

UniProt: Q06787

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development